ORIGINAL USES (ON-LABEL) Gastroesophageal reflux disease (GERD), severe erosive esophagitis, poorly responsive systemic GERD, pathologic hypersecretory conditions (Zollinger-Ellison syndrome, systemic mastocytosis, multiple endocrine adenomas); treatment of active duodenal ulcers with or without antiinfectives for Helicobacter pylori; daytime, nighttime heartburn
BRAND NAME Aciphex, Pariet
DRUG CLASS
Gastrointestinal, Proton Pump Inhibitor
DESCRIPTION
Suppresses gastric acid secretion by blocking "acid (proton) pump" within gastric parietal cells.
POTENTIAL SIDE EFFECTS
include headache, diarrhoea, rashes, itching, dizziness, nausea and vomiting, constipation, flatulence, muscle and joint pain, chest pain, inflammation of the mouth lining, cough, and a running nose.
CAUTIONS
Do not take Aciphex if you have had an allergic reaction to it or are allergic to any ingredient in this medicine.
Before you begin taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist.
DRUG INTERACTIONS
Increased serum levels of rabeprazole: benzodiazepines, phenytoin, clarithromycin. Decreased levels of rabeprazole: sucralfate
FOOD INTERACTIONS
Take 30 minutes before breakfast (and if twice a day, 30 minutes before evening meal).
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category B. Excreted in breast milk. Consult your doctor prior to initiation of breast-feeding.
SPECIAL INFORMATION
Sustained action tablets should be swallowed whole, do not chew, crush, or split the tablets.
Report severe headache, worsening of symptoms, fever, chills.
