Brand Name: Glucotrol XL
Generic Name: Glipizide sr

Glipizide

(GLIP-ih-zide)

ORIGINAL USES (ON-LABEL)
Type 2 diabetes mellitus

BRAND NAME
Glucotrol, Glucotrol XL

DRUG CLASS
Antidiabetic/Sulfonylurea (2nd generation)

DESCRIPTION
Glucotrol is a drug used to treat non-insulin dependent maturity onset diabetes (Type II). It acts by stimulating the meal-induced release of insulin from the pancreas.

POTENTIAL SIDE EFFECTS
The most common side effects are: nervousness, tremor, diarrhea, and flatulence. The incidence of excessive lowering of blood sugar (hypoglycemia) is less than 4%.

CAUTIONS

• Careful monitoring of blood glucose on a once or twice daily basis should be employed
• Contraindicated with allergy to sulfonylureas; diabetes with ketoacidosis, sole therapy of type 1 diabetes or diabetes complicated by pregnancy, diabetes complicated by fever, severe infections, severe trauma, major surgery, ketosis, acidosis, coma (insulin is indicated); type 1 diabetes, serious hepatic impairment, serious renal impairment.
• Use cautiously with uremia, thyroid or endocrine impairment, glycosuria, hyperglycemia associated with primary renal disease; labor and delivery (if glipizide is used during pregnancy, discontinue drug at least 1 mo before delivery); lactation; pregnancy.

DRUG INTERACTIONS
The blood level and activity of Glucotrol may be potentiated when taken with Diflucan (fluconazole), an oral antifungal drug. This combination should be avoided if possible.

FOOD INTERACTIONS
Alcohol

HERBAL INTERACTIONS
see Amaryl

PREGNANCY AND BREAST-FEEDING CAUTIONS
Pregnancy category C; inappropriate for use during pregnancy due to inadequate for blood glucose control, potential for prolonged neonatal hypoglycemia, and risk of congenital abnormalities.

SPECIAL INFORMATION

• Absorption is delayed when taken with food. Give drug about 30 min before meal.
• Do not discontinue this medication without consulting your health care provider.
• Monitor urine or blood for glucose and ketones.
• Do not use this drug during pregnancy; consult health care provider.
• Avoid alcohol while using this drug.
• Report fever, sore throat, unusual bleeding or bruising, rash, dark urine, light-colored stools, hypoglycemic or hyperglycemic reactions.